Sirris and MEDVIA are working together on Medical Diagnostics Goes Micro and Smart, a Vlaio-funded research-to-industry tech transfer project. Sirris has produced a series of articles on microfluidics to help industry better understand what it can provide to them.
ARTICLE 6 of 7
In this article of our series on microfluidic lab-on-chips we discuss some basic principles of how to detect or quantify the amount of biochemical target in a test sample.
The detection principles consist of one or more of the following elements:
- the bioreceptor that can bind very specifically to the target
- a way to increase the concentration of the target, to make the test more sensitive
- an optional marker molecule connected to the bioreceptor to facilitate detection
- a sensor that can measure the presence or even the amount of the bound target.
Bioreceptor
Developing a suitable bioreceptor belongs to the field of biochemistry. It is important that the bioreceptor is selective, only bonding to the target and not to similar molecules in the sample, causing false positive results. The bioreceptor usually is an enzyme, an antibody or a nucleic acid.
Read the rest of the article here
Article 1: Microfluidics – how an entire lab process fits on a bank card
https://www.sirris.be/en/inspiration/microfluidics-how-entire-lab-process-fits-bank-card
Article 2: Microfluidic chip design
https://www.sirris.be/en/inspiration/microfluidic-chip-design
Article 3: Manufacturing and prototyping techniques for polymer-based microfluidic chips
https://www.sirris.be/en/inspiration/manufacturing-and-prototyping-techniques-polymer-based-microfluidic-chips-brief
Article 4: Computer vision used for detection of fluid front in microfluidic chip
https://www.sirris.be/en/inspiration/computer-vision-used-detection-fluid-front-microfluidic-chip-part-4
Article 5: Closing event of project Medical Diagnostics Goes Micro and Smart
https://www.sirris.be/en/inspiratie/slotevent-project-medical-diagnostics-goes-micro-and-smart
Article 7: Temperature control in miniaturised devices for fast medical diagnostics
https://www.sirris.be/en/inspiration/temperature-control-miniaturised-devices-fast-medical-diagnostics-part-7
